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When skeletal muscle is hypoperfused, metabolites accumulate and trigger muscle metaboreflex activation (MMA) (345), further promoting vasoconstriction in skeletal muscle

However, upon hyperthermic stress, HSV-1 antigens were found to be expressed in multiple neurons in IFN--deficient mice and only in a single neuron in the control mice, and was followed by a higher frequency of viral reactivation in the IFN--incompetent mice (89)

Persistent exertional intolerance after COVID-19: insights from invasive cardiopulmonary exercise testing