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Skin tone usually returns gradually to its natural baseline if treatments are discontinued

Protects against bleomycin-induced pulmonary fibrosis in mice via anti-inflammatory and anti-fibrotic mechanisms 2,3

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Lipofuscin is another pigment which increases in the myocardium, skeletal muscle, liver etc with increasing age.1 Lipofuscin is biochemically distinct from melanin and shows a characteristic autofluorescence.2 Non-aged related deposition of lipofuscin occurs in the melanosis coli (so-called "brown bowel syndrome") as described below, as well as in many other organs, such as the thyroid, oesophagus, and the gall bladder.1 This condition, whereby the normal pinkish colonic mucosa became diffusely infiltrated by dark pigmentation, was described as early as 1825