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The clinical relevance of APAP toxicity makes understanding mechanisms of cell death induced by this drug critical for the identification of therapeutic targets and discovery of antidotes

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Diseases with an autoimmune component damage particular cells' mitochondria

The cytosolic CHAC proteins have a GCT-fold, which places them within the GCT protein family ( FIGURE 2 Beyond CHAC1 and CHAC2, additional ChaC-like enzymes broaden the functional spectrum of this protein family