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In those preclinical models, BPC-157 has been associated with effects on angiogenesis, on growth-factor expression including VEGF and FGF, and on the nitric oxide system

matrix metalloproteinase-9 (MMP-9), S100 calcium-binding protein A8 (S100A8), S100 calcium-binding protein A9 (S100A9), Bv8, and high mobility group box 1 (HMGB1) (73, 78, 79, 169, 170)

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When to Discontinue Use Stop using copper peptides and consult a dermatologist if you experience: Persistent irritation lasting more than a week Worsening of existing skin conditions Signs of an allergic reaction Unexpected changes in skin pigmentation Any reaction that concerns you Remember that achieving optimal results requires patience, visible improvements typically become apparent after 4-6 weeks of consistent use, with continued enhancement over several months