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In our study, increased IL-8 levels in sera correlated with disease stage, suggesting that this durable pro-inflammatory mediator might be a useful marker of inflammation in ALS progression

In addition, as caspases are oxidant stress sensitive exhibiting dual regulation by ROS, it is conceivable that overt oxidative stress and ROS generation may block caspase activation despite release of apoptosis factors from mitochondria

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Xu X, Lai Y, Hua Z-C (2019) Apoptosis and apoptotic body: disease message and therapeutic target potentials