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Doses of 2 to 4 times the therapeutic dose have only small effects, but the effect increases rapidly with doses above 8 times the normal therapeutic dose if P-450 activity is elevated

By the end of study, 38 participants had remained, resulting in an 88% adherence rate

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Several studies have shown that cyclic RGD, such as the cyclic polymeric RGD-containing peptides, compared with linear RGD or monomeric cyclic types, exhibits strong binding activity toward integrin targets [138, 139]