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Pediatrics 127:195204 Miller JL, Linville TD, Dykens EM (2014) Effects of metformin in children and adolescents with PraderWilli syndrome and early-onset morbid obesity: a pilot study

Fat stored around the belly, arms, or thighs can be more resistant, especially if your activity levels are limited or your metabolism has slowed down over time

Retinopathy, Macular Degeneration, and NAION GLP-1 medications may be linked to certain eye complications, mainly in people with diabetes who already have eye disease and experience rapid improvements in blood sugar

Step 2: Assess risk features Determine whether the patient is in dose escalation, has active GI symptoms, uses a high dose, has known gastroparesis, has long-standing diabetes with autonomic neuropathy, has severe GERD or hiatal hernia, or is undergoing general anesthesia/deep sedation