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A lizard that chews its venom in rather than injecting it, sleeps through most of its own existence and whose biology gave medicine one of its most important drug classes in modern history

however, pericentral zonation of liver damage occurred despite CYP-inhibition, suggesting that while CYPs do indeed detoxify OTA, other pericentrally located enzymes, which remain to be identified, metabolically activate OTA

Add to this complexity the high cost of making and formulating such peptides, and a small molecule drug starts to look much more attractive