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The most common side effects are gastrointestinal: nausea, vomiting, diarrhea, and constipation, particularly during the dose escalation phase when your body is adjusting to the medication

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These results are evidence that the ability to modulate neuronal excitability was weakened due to the variant, highlighted by a reduction in GABAergic feedback inhibition, and that the loss of the PI3KC2B kinase weakened inhibitory input

This guide explains BMI requirements, how qualification works, and what patients should expect during the evaluation process