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Clin Chem 64:6471

Millar TM, Stevens CR, Benjamin N, Eisenthal R, Harrison R, Blake DR (1998) Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions

33 Moreover, through the technology of whole-exome sequencing, NF1 , that encodes a negative regulator of RAS, has been identified as the third most frequently mutated gene in melanoma after BRAF and NRAS