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10.1016/S0140-6736(18)31948-2 [DOI] [PubMed] [Google Scholar] Mansur RB, Lee Y, Subramaniapillai M, Brietzke E, McIntyre RS (2018) Cognitive dysfunction and metabolic comorbidities in mood disorders: A repurposing opportunity for glucagon-like peptide 1 receptor agonists
Understanding the potential benefits naturally leads to considering the trade-offs, which is why side effects and clinical considerations are an important next step
Although clinical trials have failed to show their efficacy, a recent reanalysis of these studies suggested that these drugs may benefit AD patients with potentially greater therapeutic efficacy in those homozygous for the APOE 4 allele (Storck and Pietrzik, 2017), though it is not known whether the modulation of LRP-1 plays any role
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