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Horses most likely to benefit from milk thistle include older horses, horses with liver stress, and horses exposed to environmental toxins or medications that may affect liver function

However, whether the neuroprotection occurs primarily within the dopamine neuron 38 , at extracellular 37 sites, or in glia remains unresolved

Timing the combination protocol requires balancing injectable and topical schedules

Weeks 1-4: 1mg weekly (4mg total, small portion of first vial) Weeks 5-8: 2mg weekly (8mg total) Weeks 9-12: 4mg weekly (16mg total, finish first vial and start second) Weeks 13-16: 6mg weekly (24mg total, continue through second vial) Weeks 17-20: 8mg weekly (32mg total) Weeks 21-24: 8mg weekly maintenance (32mg total) Total peptide required: 116mg over 24 weeks Vials needed: 6 x 20mg vials with some remaining This protocol reaches 8mg maintenance by week 17 and holds there through week 24