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Xiong M, Zhang Q, Hu W, et al

Tsirtsakis A

In a normal cellular state, NRF2 is sequestered and polyubiquitinated by the constitutively active E3 ubiquitin ligase Kelch-like ECH-associated protein 1 (KEAP1), accelerating NRF2 turnover (20)

Additionally, a significant trial demonstrated an average weight loss of 12.4% from baseline weight over 68 weeks FDA approval: Wegovy received FDA approval on June 4, 2021, for long-term weight management in adults with obesity or those being overweight, marking it as a recent advancement in weight loss treatments The safety profile of Wegovy includes several important considerations: Potential risks: Users should be aware of serious side effects like thyroid tumors, pancreatitis, gallbladder problems, and increased heart rate, among others Drug interactions: Its crucial to inform healthcare providers of all medications taken, as Wegovy can interact with other drugs, especially those used for diabetes management