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Similarly, in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model, GLP-1 analogues were reported to protect the brain from MPTP-induced pathological effects, such as movement disorders, increased levels of -synuclein, chronic inflammation in the brain, loss of dopaminergic neurons, oxidative stress, and expression of growth factors (65)
GLP-1 agonists bind to the GLP-1 receptor and stimulate it to produce a physiological response, such as an increase in insulin sensitivity or appetite suppression
Diabetes Obes Metab 2017;19:1233-41.PubMed 59
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