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The appetite suppression caused by GLP-1 therapy can sometimes feel like emotional blunting because eating activates the brain's reward system in most people

The Journal of the American Medical Association published an article in June 2024 proving the point

Renoprotective effects of berberine as adjuvant therapy for hypertensive patients with type 2 diabetes mellitus: Evaluation via biochemical markers and color Doppler ultrasonography

This means that alongside toxic compounds, binders like activated charcoal, bentonite clay, and prescription Cholestyramine will also bind to essential minerals, vitamins, and dietary fats in the gut