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While missing one weekly dose of a GLP-1 or GIP/GLP-1 receptor agonist is generally not medically dangerous, prolonged interruption can lead to return of appetite, potential weight regain, and in patients with type 2 diabetes, deterioration of glycemic control

The most important thing you can do is start, be consistent, and give it the time it needs to work

Anthony Brissett attributed the demand to fat disappearing from the face faster than skin adapts, describing patient complaints of hollowed cheeks, increased skin laxity, and more pronounced jowls