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Receptors that also heterodimerise with RXR, such as VDR, can also be affected by RXR binding, and receptor competition for RXR heterodimerisation within a given tissue, is a broader consideration ( In relation to the cellular and tissue level, for adipogenesis test method models, whilst the weight of evidence appears to be stronger for the promotion of lipid accumulation in murine in vitro cell models (especially in 3T3-L1 cells), there is greater uncertainty in humans/human in vitro cell models

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It is crucial to acknowledge that the occurrence of adverse events, especially those affecting the liver due to orlistat, might be underrepresented in published reports [72]