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Comprising the subunits solute carrier family seven member 11 (SLC7A11) and solute carrier family three member 2 (SLC3A2), System Xc is a vital antioxidant System, facilitating the 1:1 exchange of cystine and glutamate across the cell membrane (Dixon et al., 2014)

The transcriptional activation of genes encoding other enzymes of the PPP also occurs in response to oxidative stress and the demands of increased anabolic metabolism

Integrated microbiomic and metabolomics insight into the ameliorating mechanisms of dietary Polygonatum cyrtonema saponin on ulcerative colitis

Other research has suggested that melatonin may also increase the expression of antioxidant enzymes such as superoxide dismutase and glutathione peroxidase [50, 51]