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Based on in vitro and in vivo DKD models, by restoring GCLM expression, SGLT2 inhibitors ensure the availability of substrates for GSH synthesis at its source ( GCLM GSH GPX4 axis, promotes efficient detoxification of lipid peroxides, and preserves mitochondrial integrity ( Beyond antioxidant reinforcement, SGLT2 inhibitors also prevent the transition from ferroptotic injury to fibrotic remodeling by suppressing solute carrier family 7 member 7 ( SLC7A7 )

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Jan 24, 2026 You have tried everything

The 85% depletion of hepatic GSH results in a decreased GSH redox potential (E GSH )