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Other neurological symptoms such as peripheral neuropathy, paresthesias, or allodynia have not been consistently reported as adverse effects attributable to semaglutide in controlled trials

In clinical studies of GLP-1RA plus SGLT2i combination therapy, the safety profile of the combination therapy was consistent with those of the individual agents, with no unexpected findings [9]

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Challenges and Side Effects Despite their benefits, GLP-1 receptor agonists come with certain challenges: Gastrointestinal Issues: Nausea, vomiting, diarrhoea, and constipation are common side effects