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(2001), late-stage AD patients supplemented with NAC over a six month period not only tolerated the treatment well, but also demonstrated significantly improved performance on the Letter Fluency Task and the Wechsler Memory Scale Immediate Number Recall [68], although, measures of oxidative stress in peripheral blood did not differ significantly [68]

However, more intensive studies are needed to gain a better understanding of the mechanisms of action ( The present study aimed to assess the potential therapeutic effects of PA on APAP-induced hepatotoxicity and the possible underlying mechanisms through its effects on CYP2E1 gene expression, serum and tissue iron load, oxidative stress and SIRT-1 expression