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Hum Exp Toxicol

These skeletal consequences are particularly concerning given the global rise in obesity, increased use of weight loss interventions, and the aging of the population

According to the Summary of Product Characteristics (SmPC), the most common side effects include: Nausea (affecting 12-24% of patients, with frequency increasing at higher doses) Diarrhoea (reported in 13-22% of participants) Vomiting (occurring in 6-10% of patients) Constipation (affecting 5-12% of users) Abdominal pain or discomfort Dyspepsia (indigestion) Decreased appetite These effects are typically mild to moderate in severity and tend to diminish over time as the body adjusts to treatment

The lack of generic competition is a major reason for their high cost