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The authors conducted both a traditional intention-to-treat analysis (termed treatment policy estimand), where outcomes are analyzed regardless of discontinuation or change in treatment dose, which limits bias associated with dropout, as well as an analysis where observations were regardless of change in treatment dose only (trial product estimand)

This occurs because tirzepatide's appetite-suppressing effectsmediated through central nervous system GLP-1 receptors and delayed gastric emptyingreverse as drug levels decline

In animal models of diabetes, the authors show that co-administration of a lipid-lowering drug with a dipeptidyl peptidase-4 inhibitor or a glucagon-like peptide-1 agonist improved glucose tolerance and beta cell mass

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