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In addition to well-demarcated tumor appearance, cytological atypia (mild nuclear pleomorphism, increased nuclear-to-cytoplasmic ratio) and extensive depletion of reticulin trabecular framework, also reported previously in GAN DIO-NASH-HCC mice 20 , tumors displayed abnormal glutamine synthetase staining

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Treatment with proton pump inhibitors (PPIs) or H2 blockers can address the acid component, often reducing burping as a secondary benefit

Glutathione functions inside cells as a key antioxidant and detoxification compound