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Signaling Cascade As already elucidated in the previous section, GLP-1-RA have demonstrated significant effects on hMSC and other progenitor cells behavior, by modulating differentiation, enhancing cell survival and regulating inflammation through multiple intracellular pathways

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Following those promising results, a phase 1 study tested ascending doses (3, 9, 20, 40, 80, and 150 g) of SAR441255 against placebo reported a decrease in both fasting and post prandial blood glucose in the SAR441255 group