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126,127,128,129 Darolutamide (also named ODM-201), 130,131 approved for treatment of nonmetastatic CRPC by the FDA in 2019, is a novel AR inhibitor that antagonizes mutated AR, such as F877L and T878A, which confers resistance to enzalutamide and apalutamide

Below, we cover how each therapy works, what the research shows about lean mass loss on GLP-1 drugs, how a physician-supervised combination protocol is structured, and what you should know about safety and qualification