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However, the ratio of reduced to oxidized GSH (GSH/GSSG) was lower in B6 MZB than in B6 FoB indicating increased ROS in MZB (Fig

21 The top 10% of proteins within these networks were scored for network topology (connectivity and bottleneck) and used as markers of essential pathway functions, 22, 23 which were identified using the Reactome algorithm 24 plug-in for Cytoscape 2.8.2 25 (Supplementary Figure S2)

This is consistent with our hypothesis that this group would include patients in whom excitotoxic damage during acute florid illness has led to subsequent reductions in mental and neural activity mediated by glutamatergic neurotransmission [3, 4]