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[Google Scholar] 102.Kurtzhals P, Kreiner FF, Bindr RS

Starting at the standard initiation dose is still recommended, but extending each escalation step to 6-8 weeks instead of 4 weeks is a common clinical adjustment

Providers increase the dose when one of three conditions is met: the side effects at the current dose have become manageable, weight loss has plateaued below the patients goal, or enough time has passed under the titration protocol to safely advance

The FDA says it has received reports of people overdosing on compounded semaglutide, giving themselves as much as 20 times more than the intended dose of the medication