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[DOI] [PMC free article] [PubMed] [Google Scholar] 364.Shen Z., Zhang X., Tang J., Kasiappan R., Jinwal U., Li P., Hann S., Nicosia S.V., Wu J., Zhang X., et al

When doses are withdrawn use aseptic technique in order to avoid contamination and preserver solution integrity

However, the fundamental constraint remains: as an agonist of the impaired receptor itself, its mechanism is intrinsically compromised, which may limit efficacy and necessitate robust validation