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Metabolic Effects of GLP-1RA Administration The administration of GLP-1RAs, like liraglutide, exenatide, semaglutide, and lixisenatide, has multiple metabolic effects, such as glucose-dependent insulin secretion, slower gastric emptying, increased natriuresis and diuresis, increased pancreatic -cell mass, regulation of lipid metabolism, and decreased fat deposition, and has attracted considerable interest in recent years for its role in improving glycemic control and aiding weight loss in T2DM patients [48]

Their findings noted that consuming greater than RDA at approximately 1.3 g/kg/day (or 0.59 grams per pound) were beneficial, blunting the loss of lean mass

Clinical studies have shown that individuals can experience a weight reduction of approximately 24% of their total body weight during this period

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