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Kawai K, Ol IE, Perrelet A, U RH

NETs contribute to immune evasion by promoting T-cell exhaustion, decorating tumor and immune cells with PD-L1, and activating IL-17-driven pathways that impair CD8 + T cell and NK cell cytotoxicity

Summary of Study Design for CT-996: The study is a Phase 1 clinical trial, multi-centered and randomized where the goal is to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of CT-996 in overweight or obese individuals as well as patients with Type 2 Diabetes Mellitus (T2DM)

In a letter to the CEO of Novo Nordisk, Sanders contends that Novo charges Americans with obesity $1,349 a month for Wegovy, while this same exact product can be purchased for just $140 in Germany and $92 in the U.K