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This was the first study to systematically demonstrate that tirzepatide not only induces substantial weight loss but also shows improvements in sleep-disordered breathing among obese individuals

Although the majority of first-time prescriptions occurred in the 45-64 age group, a higher proportion of patients with off-label prescriptions were female (off-label: 69%, on-label: 61%) and between 18-25 (off-label: 30%, on-label: 22%)

The key strategies for minimizing regain during a short break include maintaining a high protein intake of 1.6-2.2 grams per kilogram of body weight daily, continuing or increasing resistance training to preserve muscle mass, planning meals in advance so hunger does not drive impulsive food choices, monitoring weight weekly but not daily to avoid overreacting to normal fluctuations, and staying hydrated since the body may retain more water without GLP-1 mediated effects on fluid balance

Precaution for Use in People with Diabetic Retinopathy The prevalence of both CKD and diabetic retinopathy, a microvascular complication of diabetes, is known to increase proportionally to T2DM duration [47]