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Hydrogen atoms were first added at a simulated pH of 7.0 by means of the pdb2pqr 58 and propka 59 software, and the protonation of titratable side chains was checked by visual inspection

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Persistence to treatment with novel antidiabetic drugs (dipeptidyl peptidase-4 inhibitors, sodium-glucose co-transporter-2 inhibitors, and glucagon-like peptide-1 receptor agonists) in people with type 2 diabetes: a nationwide cohort study