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GPX4 deficiency results in abnormal embryonic development compared to the deficiencies of all other GPX family members and ultimately produces lethal phenotypes in mice [123]

Chetan Gadgil for carefully reviewing our manuscript and for useful discussions

Meister, A., Tate, S

Despite this enthusiasm for apoptosis, there was limited concern that if this hypothesis were correct, potent pancaspase inhibitors could prevent all cell death and cure most diseases