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REDEFINE 1, in adults with overweight or obesity without diabetes, reported 22.7% mean weight loss for the combination at 68 weeks on the on-treatment analysis, with 60% of combination participants reaching at least 20% loss and 23% reaching at least 30% (Aronne et al., 2025)
Arrows indicate stimulation (green), inhibition (blue), and the resulting cardiovascular effects (red)
the original rodent study used 5 mg/kg, which when scaled allometrically to human equivalents suggests doses in the 5-10 mg range for a 70 kg adult, though allometric scaling from mice to humans is an imprecise science
These interventions, ranging from pharmacological methods to dietary regulation, are expected to improve the quality of life of older adults and alleviate social challenges associated with population aging
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