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Henson SM, Lanna A, Riddell NE, Franzese O, Macaulay R, Griffiths SJ, et al

The present study unveils that SP alleviates intracellular oxidative stress and promotes the pro-inflammatory M1-like to anti-inflammatory M2-like repolarization of SMs, remodeling the redox balance and suppressing synovial inflammation (Fig

You are now on the standard escalation schedule, just arriving there from a lower starting point

When addressing dimeric protein targets, the ability of dimeric therapeutic agents to antagonize paired receptors within a single molecular entity potentially offers superior therapeutic efficacy and target selectivity 15,16