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Emerging strategies are reported to include modulation of synaptic plasticity and neurotransmission, delivery of neurotrophic factors, activation of intrinsic cytoprotective pathways (e.g., Nrf2 signaling), restoration of proteostasis, and induction of regeneration via cellular reprogramming

Patients treated with spironolactone were more likely to be older, obese, and receive concurrent medical addiction therapy and less likely to receive psychotherapy and have a concurrent substance use disorder compared to patients never receiving therapy

doi: 10.1002/adhm.201701000 210 AlverCGDrabbeEIshahakMAgarwalA

Ann Thorac Surg 101(1):211-17, 2016