what does tylenol do to glutathione metabolism and liver detoxification with Glutathione & Tylenol: Safety, Metabolism

[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Kumar D, Kandl C, Hamilton CD, Shnayder Y, Tsue TT, Kakarala K, Ledgerwood L, Sun XS, Huang HJ, Girod D, Thomas SM

Toxicology assessments in rats found no organ toxicity at doses up to 10 mg/kg (approximately 1000x the effective dose), no mutagenicity in Ames testing, and no teratogenic effects

Such trials must rigorously evaluate the efficacy and safety of O-GlcNAcylation-targeting approaches in patients, with particular attention to CNS disorders where treatment options are limited

gene expression modulation (~31% of human genes per Connectivity Map analysis)