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Adriaenssens AE, Biggs EK, Darwish T et al (2019) Glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus regulate food intake

A recent analysis calculated an estimated number needed to harm of 1,066 associated with a DPP-4 inhibitor therapy (12, 4749)

FDA Status: Approved for type 2 diabetes and obesity treatment Mechanism: Dual GLP-1 and GIP receptor activation for enhanced metabolic response Average Weight Loss: 1822% of total body weight Side Effects: Nausea, occasional fatigue, or mild gastrointestinal symptoms At our Tijuana clinic, patients who qualify for Tirzepatide can enjoy greater affordability and individualized dosing options, without the high cost or wait times often experienced at clinics in the United States

Goal: Type 2 diabetes management (A1C reduction) If you prefer once-weekly injections: Semaglutide (Ozempic), tirzepatide (Mounjaro), dulaglutide (Trulicity), or efpeglenatide (Eperzan) If you prefer daily injections: Liraglutide (Victoza) or lixisenatide (Adlyxin) If you prefer oral medication: Semaglutide (Rybelsus) If cost is the primary concern: Compounded semaglutide or compounded tirzepatide (if eligible under shortage provisions) Goal: Weight loss (obesity or overweight with comorbidities) If you want maximum weight loss: Retatrutide (Retara, triple agonist, 24% mean loss) or tirzepatide (Zepbound, dual agonist, 20% to 22% mean loss) If you want proven long-term safety data: Semaglutide (Wegovy, 15% to 17% mean loss, 5+ years post-approval data) If you prefer oral medication: Orforglipron (Orfoglip, 15% mean loss, oral once daily) If cost is the primary concern: Compounded semaglutide or compounded tirzepatide Goal: Both diabetes and weight loss If you have significant obesity (BMI over 35): Tirzepatide (Mounjaro for diabetes indication, Zepbound for obesity indication