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Monoclonal antibodies (e.g., Lpathomab) sequester LPA and has demonstrated neuroprotective effects in central nervous system (CNS) injury models by neutralizing extracellular LPA (18:1) (93), but it also shows significant cross-reactivity with more abundant lipids such as LPC and PA (94)

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Lindsey Yourman, associate clinical professor in the division of geriatrics, gerontology, and palliative care at the University of California San Diego School of Medicine