In the STEP 1 trial which studied semaglutide in adults with overweight or obesity, researchers studied body mass composition as a secondary endpoint via DXA in a subpopulation of trial enrollees randomized to treatment or placebo
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Thalmann O, Shapiro B, Cui P, et al
In certain cases, underlying health conditions might also affect how the body metabolizes the drug, prompting either an increase or decrease in dose
