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Introduction Type 2 diabetes mellitus (T2DM) is a prevalent metabolic condition characterized by insulin resistance and inadequate insulin production as a result of a decline in pancreatic beta-cell activity [1]

Results announced in October 2025 demonstrated orforglipron's superiority on both HbA1c and weight endpoints, positioning it as a more effective second-line oral agent than existing oral diabetes medications

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New drug discovery methodologies must be developed in designing vaccines and small molecular drugs to combat bacterial resistance [24]