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Both medications work through the GLP-1 system, but tirzepatide adds a second receptor target that may amplify appetite control and metabolic effects

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Thus, in addition to generating cysteine, the transsulfuration pathway utilizes homocysteine, whose accumulation can be harmful, by activating the NMDA receptors causing excitotoxicity and elevated oxidative stress (Lipton et al ., 1997)

Reducing the occurrence of hypoglycemia or weight gain, as recurrent distressing side effects of traditional antidiabetic agents reduces the morale of not only the patient but also the treating physician