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Therefore, it is essential to activate neuroprotective systems such as NRF2 and its downstream antioxidant signalling, able to counteract pathological insults from highly reactive oxidant species in the brain and limit the accumulation of oxidative damage [68]

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On the other hand, seborrhea, acne, T2D and cancer are frequently observed in acromegaly with increased GH/IGF-1 signaling in comparison to healthy controls [16]

Step four: consider compounded alternatives If brand name medications are not financially viable, compounded versions offer a significantly lower-cost pathway to continued treatment