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In August 2025 it received accelerated FDA approval for the treatment of non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with moderate-to-advanced fibrosis, becoming the first GLP-1 receptor agonist approved for MASH, alongside resmetirom as the only approved therapies for this indication, on the basis of the Phase 3 ESSENCE trial in which resolution of steatohepatitis without worsening of fibrosis was achieved in 63% of patients on semaglutide versus 34% on placebo at week 72

[DOI] [PubMed] [Google Scholar] 4.Wu C., Targher G., Byrne C.D., Mao Y., Cheung T.T., Yilmaz Y., Valenti L., Mndez-Snchez N., Sookoian S., Chan W.K., et al

There is no generic semaglutide, so any provider marketing generic Ozempic or generic Wegovy is making a false claim, which is a hard red flag

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