Semaglutide and GLP-1MK-801, but not MK-801 monotherapy, lowered food intake in rats, with GLP-1MK-801 treatment resulting in a more pronounced reduction compared with semaglutide (Fig
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GLP-1R was detected in both smooth muscle and enteric plexuses, but the TTX-insensitive inhibition of contraction indicates that GLP-1 acts predominantly through a myogenic mechanism
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