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The medications work through several complementary mechanisms: Appetite suppression : Acting on receptors in the hypothalamus to reduce hunger signals and increase satiety Delayed gastric emptying : Slowing the rate at which food leaves the stomach, prolonging feelings of fullness Enhanced insulin secretion : Stimulating glucose-dependent insulin release from pancreatic beta cells Reduced glucagon secretion : Decreasing the hormone that raises blood glucose levels Clinical efficacy for weight loss has been demonstrated in clinical trials

Call your healthcare provider if you have severe low blood sugar or if you have low blood sugar more often than normal

In 2021, semaglutides weight-loss brand Wegovy (weekly injectable) was approved for obesity, followed by tirzepatide (Mounjaro) for diabetes (2022) and Zepbound (tirzepatide for obesity) in late 2023

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