Cells at 20 ~ 30% confluency were transfected with 3 g pcDNA3.3-dsRed/Sabin1-P1 or pcDNA3.3-dsRed/Mahoney-P1 formulated with Lipo3000 transfection reagent (Invitrogen), and 2 g pcDNA3.3-T7 and 2 g pT7-Replicon-eGFP were co-transfected the next day
Julianna Nikolic Chief Strategy Officer Julianna Nikolic leads strategic initiatives, focusing on growth, innovation, and patient-centered solutions in the reproductive sciences sector
Because cuproptosis preferentially targets cells with high oxidative phosphorylation (OXPHOS) dependency, whereas glycolytic tumors remain relatively resistant, it exposes a distinct metabolic vulnerability in cancer and presents unique therapeutic opportunities 165,166
In the document, the agency said it will stop accepting new applications to its CMC Development and Readiness Pilot (CDRP) at the end of April 2027, but investigational new drug (IND) applications that were previously accepted in the pilot will continue to be in the program
