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In patients with T2D, human amylin is known to accumulate in the pancreatic islets of Langerhans, forming oligomer aggregates that contribute to beta-cell damage in T2D

Then using a H 2 O 2 -induced senescent TM3 Leydig cell model, we found that FOXO4 maintains the viability of senescent Leydig cells and that the FOXO4 blocker FOXO4-DRI induces apoptosis in these senescent cells

Global estimates of the need for rehabilitation based on the global burden of disease study 2019: A systematic analysis for the global burden of disease study 2019