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A: The most frequently reported side effects are gastrointestinal: nausea, vomiting, diarrhea, and constipation

For example, conditions such as thyroid disorders , polycystic ovary syndrome (PCOS) , and insulin resistance can affect how well these medications manage appetite and metabolism

Notably, STZ-treated animals exhibit alterations in mitochondrial dynamics, including increased expression of fission proteins such as Drp1 and Fis1, accompanied by decreased levels of fusion-related proteins like Mfn2 and OPA1, particularly in the hippocampus and in the prefrontal cortex (Paidi et al., 2015

That is enhancing insulin secretion when there's glucose, and it's suppressing you from taking , the storage form of sugar and liberating that into glucose